About: Oxaliplatin     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Oxaliplatin
rdfs:subClassOf
Has_Target
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Oxaliplatin
NSC_Code
  • 266046
UMLS_CUI
  • C0069717
CAS_Registry
  • 61825-94-3
Accepted_Therapeutic_Use_For
  • Metastatic colorectal cancer; ovarian cancer
In_Clinical_Trial_For
  • Liver metastases; medulloblastoma; non-small cell lung cancer; ovarian epithelial cancer; pancreatic cancer; small bowel adenocarcinoma; supratentorial primitive neuroectodermal tumor; unspecified solid tumors
  • Atypical teratoid rhabdoid tumor; cervical cancer; colorectal cancer; endometrial cancer; esophageal cancer; gastric cancer; gastroesophageal junction adenocarcinoma; glioblastoma multiforme
FDA_UNII_Code
  • 04ZR38536J
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used with other drugs to treat colorectal cancer that is advanced or has come back. It is also being studied in the treatment of other types of cancer. Eloxatin attaches to DNA in cells and may kill cancer cells. It is a type of platinum compound.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 42374
PDQ_Closed_Trial_Search_ID
  • 42374
Chemical_Formula
  • C8H14N2O4Pt
Legacy_Concept_Name
  • Oxaliplatin
CHEBI_ID
  • CHEBI:31941
FULL_SYN
  • OxaliplatinSYDTPNSC0266046
  • oxalato (trans-l-1,2-diaminocyclohexane)platinum(II)SNNCI
  • trans-l diaminocyclohexane oxalatoplatinumSNNCI
  • OxaliplatinPTNCI
  • 1-OHPSYDTPNSC0266046
  • [SP-4-2-(1R-trans)]-(1,2,cyclohexanediamine-N,N')[ethanedioato(2--)-O,O']platinumSNNCI
  • Diaminocyclohexane OxalatoplatinumSYNCI
  • oxaliplatinPTNCI-GLOSSCDR0000045465
  • OxalatoplatinSYNCI
  • OxalatoplatinSYDTPNSC0266046
  • DACPLATSYDTPNSC0266046
  • oxalato (1R,2R-cyclohexanediamine)platinum(II)SNNCI
  • [(1R,-2R)-1,2-cyclohexanediamine-N,N'][oxalato (2--)-O,O']platinumSNNCI
  • OxalatoplatinumSYNCI
  • RP 54780SYDTPNSC0266046
  • ELOXATINSYDTPNSC0266046
  • JM-83CNNCI
  • 1-OHPABNCI
  • OxalatoplatinumSYDTPNSC0266046
  • trans-l DACH oxalatoplatinumSNNCI
  • DacplatFBNCI
  • DacotinFBNCI
  • RP-54780CNNCI
  • SR-96669CNNCI
  • EloxatinPTNCI-GLOSSCDR0000413944
  • EloxatinBRNCI
  • OXALIPLATINPTFDA04ZR38536J
  • EloxatineFBNCI
DEFINITION
  • An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane (DACH) and with an oxalate ligand as a 'leaving group.' A 'leaving group' is an atom or a group of atoms that is displaced as a stable species taking with it the bonding electrons. After displacement of the labile oxalate ligand leaving group, active oxaliplatin derivatives, such as monoaquo and diaquo DACH platinum, alkylate macromolecules, forming both inter- and intra-strand platinum-DNA crosslinks, which result in inhibition of DNA replication and transcription and cell-cycle nonspecific cytotoxicity. The DACH side chain appears to inhibit alkylating-agent resistance. (NCI04)NCI
code
  • C1181
is someValuesFrom of
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 26 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software