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AttributesValues
rdf:type
rdfs:label
  • Mitomycin A
rdfs:subClassOf
Semantic_Type
  • Antibiotic
  • Organic Chemical
Preferred_Name
  • Mitomycin A
NSC_Code
  • 75986
UMLS_CUI
  • C0066608
CAS_Registry
  • 4055-39-4
Legacy_Concept_Name
  • Mitomycin_A
FULL_SYN
  • Mitomycin APTNCI
  • Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-6,8a-dimethoxy-5-methyl-, carbamate (ester)SNNCI
  • Mitomycin ASYDTPNSC0075986
DEFINITION
  • A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus. Bioreduced mitomycin A generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Mitomycin A is more toxic than mitomycin C due to increased and nonselective DNA cross-linking in both aerobic and hypoxic cells. (NCI04)NCI
code
  • C1164
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