About: Fludarabine

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Attributes	Values
rdf:type	Class
rdfs:label	Fludarabine
rdfs:subClassOf	Purine Antagonist Ribonucleotide Reductase Inhibitor
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name	Fludarabine
NSC_Code	118218
UMLS_CUI	C0059985
CAS_Registry	21679-14-1
Accepted_Therapeutic_Use_For	Acute nonlymphocytic leukemia; Chronic lymphocytic leukemia; Indolent Non - Hodkins Lymphoma
In_Clinical_Trial_For	Sickle Cell anemia; Thalassemia Multiple myeloma; Myeloproliferative and Myelodysplastic Diseases; Renal cell cancer; Scleroderma;
FDA_UNII_Code	P2K93U8740
Contributing_Source	FDA
ALT_DEFINITION	The active ingredient in a drug used to treat B-cell chronic lymphocytic leukemia (CLL) that has not responded to treatment with other anticancer drugs or that has gotten worse. Fludarabine blocks cells from making DNA and may kill cancer cells. It is a type of purine antagonist and a type of ribonucleotide reductase inhibitor.NCI-GLOSS
Chemical_Formula	C10H12FN5O4
Legacy_Concept_Name	Fludarabine
FULL_SYN	FludarabinePTNCI fludarabinePTNCI-GLOSSCDR0000045200 2-FluorovidarabineSNNCI 2-Fluoro-9-beta-arabinofuranosyladenineSNNCI FLUDARABINEPTFDAP2K93U8740 9-Beta-D-arabinofuranosyl-2-fluoroadenineSNNCI 9-Beta-D-arabinofuranosyl-2-fluoro-9H-purin-6-amineSNNCI FluradosaBRNCI
DEFINITION	A fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Administered parenterally as a phosphate salt, fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth. (NCI04)NCI
code	C1094
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