About: Porfimer Sodium     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Porfimer Sodium
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Porfimer Sodium
NSC_Code
  • 265328
  • 603062
UMLS_CUI
  • C0058031
CAS_Registry
  • 87806-31-3
Accepted_Therapeutic_Use_For
  • Photosensitizer, bladder, esophagel, gastric, lung and rectal cancer
In_Clinical_Trial_For
  • Photosensitizer, brain tumor
FDA_UNII_Code
  • Y3834SIK5F
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat some types of cancer. When absorbed by cancer cells and exposed to light, porfimer sodium becomes active and kills the cancer cells. It is a type of photodynamic therapy agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 40294
PDQ_Closed_Trial_Search_ID
  • 40294
Chemical_Formula
  • (C34H35N4NaO5)n.(C34H33N4NaO4)n
Legacy_Concept_Name
  • Porfimer_Sodium
CHEBI_ID
  • CHEBI:60773
FULL_SYN
  • dihematoporphyrin etherSYNCI-GLOSSCDR0000046110
  • Photofrin IISYDTPNSC0603062
  • Photofrin IISYNCI
  • Dihematoporphyrin EtherSYNCI
  • Dihematoporphyrin EsterSYNCI
  • DHEABNCI
  • PORFIMER SODIUMPTFDAY3834SIK5F
  • Porfimer SodiumPTNCI
  • porfimer sodiumPTNCI-GLOSSCDR0000045291
  • CL-184116CNNCI
DEFINITION
  • The sodium salt of a mixture of oligomers formed by ether and ester linkages of up to eight porphyrin units with photodynamic activity. Absorbed selectively by tumor cells, porfimer produces oxygen radicals after activation by 630 nm wavelength laser light, resulting in tumor cell cytotoxicity. In addition, tumor cell death may occur due to ischemic necrosis secondary to vascular occlusion that appears to be partly mediated by the release of thromboxane A2.NCI
code
  • C1071
is someValuesFrom of
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