About: Lutetium Lu 177 DOTA-Tetulomab     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Lutetium Lu 177 DOTA-Tetulomab
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Lutetium Lu 177 DOTA-Tetulomab
PDQ_Open_Trial_Search_ID
  • 746917
PDQ_Closed_Trial_Search_ID
  • 746917
FULL_SYN
  • 177Lu-DOTA-HH1SYNCI
  • Lutetium Lu 177 DOTA-TetulomabPTNCI
  • 177Lu-Dota-TetulomabSYNCI
  • 177Lu-HH1SYNCI
DEFINITION
  • A radioimmunoconjugate, which consists of a monoclonal antibody against the cell-surface antigen CD37 covalently linked, via the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA), to the beta-emitting radioisotope lutetium Lu 177, with potential antineoplastic activity. The antibody moiety of lutetium Lu 177 DOTA-tetulomab binds to CD37 on tumor B-cells. Upon internalization, the radioisotope moiety delivers a cytotoxic dose of beta radiation to CD37-expressing tumor cells. CD37, a transmembrane glycoprotein, is overexpressed in B-cell malignancies.NCI
code
  • C105403
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