About: Monocarboxylate Transporter 1 Inhibitor AZD3965     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Monocarboxylate Transporter 1 Inhibitor AZD3965
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Monocarboxylate Transporter 1 Inhibitor AZD3965
PDQ_Open_Trial_Search_ID
  • 746809
PDQ_Closed_Trial_Search_ID
  • 746809
FULL_SYN
  • Monocarboxylate Transporter 1 Inhibitor AZD3965PTNCI
  • AZD3965CNNCI
  • MCT1 Inhibitor AZD3965SYNCI
DEFINITION
  • An orally available inhibitor of monocarboxylate transporter 1 (MCT1), with potential antineoplastic activity. Upon oral administration, MCT1 inhibitor AZD3965 binds to MCT1 and prevents the transport of lactate into and out of the cell. This leads to an accumulation of lactate, intracellular acidification, and eventually cancer cell death. MCT1, a protein overexpressed on tumor cells, is responsible for the transport of monocarboxylates across the cell membrane and plays a key role in cell metabolism.NCI
code
  • C105399
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