About: Phenethyl Isothiocyanate-containing Watercress Juice     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Phenethyl Isothiocyanate-containing Watercress Juice
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Phenethyl Isothiocyanate-containing Watercress Juice
PDQ_Open_Trial_Search_ID
  • 746772
PDQ_Closed_Trial_Search_ID
  • 746772
FULL_SYN
  • PEITC-containing Watercress JuiceSYNCI
  • Phenethyl Isothiocyanate-containing Watercress JuicePTNCI
DEFINITION
  • A juice extracted from watercress containing high amounts of phenethyl isothiocyanate (PEITC), with potential chemopreventive and antitumor activities. Although the mechanism(s) of action through which PEITC exerts its effect(s) has yet to be fully elucidated, PEITC is able to induce apoptosis in tumor cells through the induction of reactive oxygen species (ROS). Additionally, PEITC is able to modulate extracellular signal-regulated kinases (ERK), c-Jun N-terminal kinase (JNK) and mitogen-activated protein kinase (MAPK) signal transduction pathways, activating the expression of stress-responsive genes and eventually inducing apoptosis. PEITC also inhibits the expression of genes involved in tumor progression such as HIF, STAT-3, HER2, BCL-XL, and XIAP and induces the expression of genes involved in tumor suppression such as p53, ATF-2, and p57. Furthermore, this agent has been shown to reactivate the gene expression of certain detoxification enzymes.NCI
code
  • C105392
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