About: Cathepsin-Activatable Cy5 Fluorescent Imaging Probe LUM015     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Cathepsin-Activatable Cy5 Fluorescent Imaging Probe LUM015
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Cathepsin-Activatable Cy5 Fluorescent Imaging Probe LUM015
PDQ_Open_Trial_Search_ID
  • 746336
PDQ_Closed_Trial_Search_ID
  • 746336
FULL_SYN
  • LUM015CNNCI
  • Cathepsin-Activatable Cy5 Fluorescent Imaging Probe LUM015PTNCI
DEFINITION
  • A cathepsin-activatable fluorescent probe with imaging activity. The cathepsin-activatable fluorescent probe LUM015 contains the Cy5 fluorophore linked, via a pan-cathepsin protease cleavable peptide, to a fluorescent quencher. Upon injection, the peptide in LUM015 can be cleaved by cathepsins overexpressed by tumor cells, which releases the quencher and activates the fluorophore. Upon imaging, tumor cells expressing cathepsin family proteases can be detected.NCI
code
  • C105147
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