About: Cancer Stemness Kinase Inhibitor BBI503     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Cancer Stemness Kinase Inhibitor BBI503
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Cancer Stemness Kinase Inhibitor BBI503
PDQ_Open_Trial_Search_ID
  • 746133
PDQ_Closed_Trial_Search_ID
  • 746133
FULL_SYN
  • BBI503CNNCI
  • Cancer Stemness Kinase Inhibitor BBI503PTNCI
DEFINITION
  • An orally available cancer cell stemness kinase inhibitor with potential antineoplastic activity. Even though the exact target has not been fully elucidated, BBI503 targets and inhibits one or more pathways involved in cancer stem cell survival. As a result, cancer stem cell (CSC) growth as well as heterogeneous cancer cell growth is inhibited. CSCs, self-replicating cells able to differentiate into heterogeneous cancer cells, appear to be responsible for both tumor relapse and metastasis.NCI
code
  • C104745
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