About: Recombinant Adenovirus-Interferon/Syn3     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Recombinant Adenovirus-Interferon/Syn3
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Recombinant Adenovirus-Interferon/Syn3
PDQ_Open_Trial_Search_ID
  • 746097
PDQ_Closed_Trial_Search_ID
  • 746097
FULL_SYN
  • InstiladrinFBNCI
  • rAd-IFN/Syn3ABNCI
  • Recombinant Adenovirus-Interferon With Syn3SYNCI
  • Recombinant Adenovirus-Interferon/Syn3PTNCI
DEFINITION
  • A non-replicating recombinant adenovirus type 5 (Ad5)-vector encoding the gene for interferon alpha-2b (IFN alpha-2b) and the gene transfer enhancement agent Syn 3, with potential antineoplastic activity. Upon intravesical administration, recombinant adenovirus-interferon with Syn3 transfects both cancerous and normal bladder cells, and the adenovirus secretes interferon (IFN alpha-2b) into the bladder. IFN exerts a direct antitumor killing effect and a bystander effect, thereby killing adjacent, non-transfected cancerous bladder cells. Syn 3 enhances the ability of the adenoviral vector to transfect cells.NCI
code
  • C104743
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