About: Gene-Modified HIV-Protected Hematopoietic Stem Cells     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Gene-Modified HIV-Protected Hematopoietic Stem Cells
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Gene-Modified HIV-Protected Hematopoietic Stem Cells
PDQ_Open_Trial_Search_ID
  • 745547
PDQ_Closed_Trial_Search_ID
  • 745547
FULL_SYN
  • Gene-Modified HIV-Protected Hematopoietic Stem CellsPTNCI
DEFINITION
  • Autologous hematopoietic stem cells (HSCs) genetically modified to be resistant to infection by human immunodeficiency virus (HIV). Allogeneic human autologous HSCs are isolated and transduced ex vivo with three different anti-HIV genes. Upon infusion into the HIV-infected lymphoma patient, the gene-modified HIV-protected HSCs are resistant to HIV entry and replication thereby preventing HIV infection in these proliferating stem cells and any differentiated cells that they give rise to. This results in the formation of immune cells resistant to HIV which also may be able to destroy HIV-infected cells.NCI
code
  • C104415
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