About: Geranylgeranyltransferase I Inhibitor     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Geranylgeranyltransferase I Inhibitor
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Geranylgeranyltransferase I Inhibitor
PDQ_Open_Trial_Search_ID
  • 745403
PDQ_Closed_Trial_Search_ID
  • 745403
FULL_SYN
  • Geranylgeranyltransferase I InhibitorPTNCI
  • GGTI-ISYNCI
  • GGTase-I InhibitorSYNCI
DEFINITION
  • A substance that inhibits protein geranylgeranyltransferase type 1 (GGTase-I), with potential antineoplastic activity. GGTase-I is involved in the posttranslational modification of a number of oncogenic GTPases, including K-Ras, N-Ras, RhoA, RhoC, Cdc42, RalA, RalB and Rac1. Inhibition of the prenylation of these oncogenic proteins inhibits both their oncogenic activity and membrane localization. This may result in cell cycle arrest and apoptosis. Protein geranylgeranylation, catayzed by GGTase-I, plays a critical role in malignant transformation and cancer cell proliferation, migration and invasion.NCI
code
  • C104414
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