About: PI3K-delta Inhibitor TGR-1202     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • PI3K-delta Inhibitor TGR-1202
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • PI3K-delta Inhibitor TGR-1202
PDQ_Open_Trial_Search_ID
  • 745293
PDQ_Closed_Trial_Search_ID
  • 745293
FULL_SYN
  • RP5264CNNCI
  • PI3K-delta Inhibitor TGR-1202PTNCI
  • TGR-1202CNNCI
DEFINITION
  • An orally bioavailable, selective inhibitor of the delta isoform of the 110 kDa catalytic subunit of class I phosphoinositide-3 kinases (PI3K) with potential antineoplastic activity. PI3K-delta inhibitor TGR-1202 inhibits PI3K and prevents the activation of the PI3K/AKT kinase signaling pathway. This decreases proliferation and induces cell death in susceptible tumor cells. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in tumor cells and cells of the hematopoietic lineage. The targeted inhibition of PI3K-delta allows for PI3K signaling in normal, non-neoplastic cells. PI3K, an enzyme often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival.NCI
code
  • C104413
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