About: p53/HDM2 Interaction Inhibitor CGM097     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • p53/HDM2 Interaction Inhibitor CGM097
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • p53/HDM2 Interaction Inhibitor CGM097
PDQ_Open_Trial_Search_ID
  • 744999
PDQ_Closed_Trial_Search_ID
  • 744999
FULL_SYN
  • HDM2/p53 Inhibitor CGM097SYNCI
  • p53/HDM2 Interaction Inhibitor CGM097PTNCI
  • CGM097CNNCI
DEFINITION
  • An orally bioavailable HDM2 (human homolog of double minute 2) antagonist with potential antineoplastic activity. Upon oral administration, p53/HDM2 interaction inhibitor CGM097 inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of p53 signaling and, thus, the p53-mediated induction of tumor cell apoptosis. HDM2, a zinc finger nuclear phosphoprotein, is a negative regulator of the p53 pathway, often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival.NCI
code
  • C104280
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