About: Cefepime Hydrochloride     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Cefepime Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Antibiotic
  • Organic Chemical
Preferred_Name
  • Cefepime Hydrochloride
UMLS_CUI
  • C0771284
CAS_Registry
  • 123171-59-5
Accepted_Therapeutic_Use_For
  • Upper respiratory tract and urinary tract infections; febrile neutropenic conditions
FDA_UNII_Code
  • I8X1O0607P
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 38350
PDQ_Closed_Trial_Search_ID
  • 38350
Chemical_Formula
  • C19H24N6O5S2.2ClH.H2O
Legacy_Concept_Name
  • Cefepime
CHEBI_ID
  • CHEBI:31368
FULL_SYN
  • Cefepime HydrochloridePTNCI
  • CEFEPIME HYDROCHLORIDEPTFDAI8X1O0607P
  • MaxipimeBRNCI
  • Pyrrolidinium, 1-((7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-1-methyl-, hydroxide, inner salt, (6R-(6alpha,7beta(Z)))-SNNCI
DEFINITION
  • The hydrochloride salt of a semi-synthetic, beta-lactamase-resistant, fourth-generation cephalosporin antibiotic derived from an Acremonium fungal species with broad-spectrum bactericidal activity. Administered parenterally, cefepime inhibits bacterial cell wall synthesis by binding to and inactivating penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity, resulting in a reduction of bacterial cell wall stability and cell lysis. This agent is more active against a variety of Gram-positive pathogens compared to third-generation cephalosporins.NCI
code
  • C1041
is Has_Salt_Form of
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