About: PI3K/HDAC Inhibitor CUDC-907     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • PI3K/HDAC Inhibitor CUDC-907
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • PI3K/HDAC Inhibitor CUDC-907
NCI_META_CUI
  • CL438390
PDQ_Open_Trial_Search_ID
  • 743908
PDQ_Closed_Trial_Search_ID
  • 743908
FULL_SYN
  • PI3K/HDAC Inhibitor CUDC-907PTNCI
  • CUDC-907CNNCI
DEFINITION
  • An orally bioavailable inhibitor of both phosphoinositide 3-kinase (PI3K) class I and pan histone deacetylase (HDAC) enzymes, with potential antineoplastic activity. Upon oral administration, CUDC-907 inhibits the activity of both PI3K class I isoforms and HDAC, thereby preventing the activation of the PI3K-AKT-mTOR signal transduction pathway that is often overactivated in many cancer cell types. This may prevent growth of PI3K and/or HDAC-expressing tumor cells. CUDC-907 shows an increased inhibition of tumor cell growth and induction of apoptosis when compared to inhibitors that target either PI3K or HDAC.NCI
code
  • C104008
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