About: FAP-specific CD8-positive T Cells     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • FAP-specific CD8-positive T Cells
rdfs:subClassOf
Semantic_Type
  • Cell
  • Pharmacologic Substance
Preferred_Name
  • FAP-specific CD8-positive T Cells
NCI_META_CUI
  • CL438309
PDQ_Open_Trial_Search_ID
  • 742755
PDQ_Closed_Trial_Search_ID
  • 742755
FULL_SYN
  • FAP-specific CD8-positive T CellsPTNCI
DEFINITION
  • A preparation of CD8-positive T cells specific for human fibroblast activating protein (FAP) with potential immunopotentiating activity. T cells have been genetically modified to express a chimeric antigen receptor specific for FAP. Upon infusion, the FAP-specific CD8-positive T cells bind to FAP-expressing tumor cells and exhibit a selective toxicity to tumor cells. This may result in both tumor cell lysis and inhibition of tumor cell growth. FAP, a cell surface glycoprotein, is overexpressed on tumor-associated fibroblasts but minimally expressed on normal, healthy cells.NCI
code
  • C103829
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