About: Galectin-1 Inhibitor OTX008     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Galectin-1 Inhibitor OTX008
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Galectin-1 Inhibitor OTX008
NCI_META_CUI
  • CL438308
PDQ_Open_Trial_Search_ID
  • 742751
PDQ_Closed_Trial_Search_ID
  • 742751
FULL_SYN
  • Galectin-1 Inhibitor OTX008PTNCI
  • OTX008CNNCI
  • Gal-1 Inhibitor OTX008SYNCI
DEFINITION
  • A calixarene-based compound and galectin-1 (Gal-1) inhibitor with potential anti-angiogenic and antineoplastic activities. Upon subcutaneous administration, galectin-1 inhibitor OTX008 binds Gal-1 which leads to Gal-1 oxidation and proteosomal degradation, through an as of yet not fully elucidated mechanism, and eventually downregulation of Gal-1. This decreases tumor cell growth and inhibits angiogenesis. Gal-1, a multifunctional carbohydrate-binding protein, is often overexpressed on tumor cells and plays a key role in cancer cell proliferation, apoptosis, tumor angiogenesis and evasion of immune responses.NCI
code
  • C103828
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