About: Smoothened Receptor Antagonist LY294068

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Attributes	Values
rdf:type	Class
rdfs:label	Smoothened Receptor Antagonist LY294068
rdfs:subClassOf	Signal Transduction Inhibitor
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Smoothened Receptor Antagonist LY294068
NCI_META_CUI	CL433735
PDQ_Open_Trial_Search_ID	688313
PDQ_Closed_Trial_Search_ID	688313
FULL_SYN	4-Fluoro-N-methyl-N-(1-(4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl)piperidin-4-yl)-2-(trifluoromethyl)benzamideSNNCI Smoothened Receptor Antagonist LY294068PTNCI LY2940680CNNCI
DEFINITION	An orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic activity. Smo inhibitor LY2940680 inhibits signaling that is mediated by the Hh pathway protein Smo, which may result in a suppression of the Hh signaling pathway and may lead to the inhibition of the proliferation of tumor cells in which this pathway is abnormally activated. The Hh signaling pathway plays an important role in cellular growth, differentiation and repair; constitutive activation of this pathway is associated with uncontrolled cellular proliferation and has been observed in a variety of cancers.NCI
code	C103826

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