About: Smac Mimetic GDC-0917     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Smac Mimetic GDC-0917
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Smac Mimetic GDC-0917
NCI_META_CUI
  • CL433733
PDQ_Open_Trial_Search_ID
  • 688091
PDQ_Closed_Trial_Search_ID
  • 688091
FULL_SYN
  • IAP Antagonist GDC-0917SYNCI
  • SMAC/DIABLO Mimetic GDC-0917SYNCI
  • GDC-0917CNNCI
  • Smac Mimetic GDC-0917PTNCI
DEFINITION
  • An orally available, monovalent mimetic of second mitochondrial-derived activator of caspases (Smac/DIABLO) and inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity. Smac mimetic GDC-0917 binds to the Smac binding groove on IAPs, including the direct caspase inhibitor X chromosome-linked IAP (XIAP) and the cellular IAPs 1 and 2. This inhibits the activities of these IAPs and promotes the induction of apoptosis through apoptotic signaling pathways. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding to and inhibiting active caspases-3, -7 and -9 via their baculoviral lAP repeat (BIR) domains.NCI
code
  • C103825
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