About: Fluorine F 18 d-FMAU     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Fluorine F 18 d-FMAU
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Fluorine F 18 d-FMAU
NCI_META_CUI
  • CL438129
PDQ_Open_Trial_Search_ID
  • 741648
PDQ_Closed_Trial_Search_ID
  • 741648
FULL_SYN
  • 2'-Deoxy-2'-[18F]fluoro-5-methyl-1-beta-D-arabinofuranosyluracilSNNCI
  • 1-(2'-Deoxy-2'-[18F]fluoro-beta-D-arabinofuranosyl)thymineSNNCI
  • Fluorine F 18 d-FMAUPTNCI
DEFINITION
  • A radioconjugate comprised of the synthetic pyrimidine analogue 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)thymine (d-FMAU) labeled with the radioisotope fluorine F 18 (18F-d-FMAU), that can potentially be used as an imaging agent upon positron emission tomography (PET). Upon administration, fluorine F 18 FMAU is distributed and taken up by cells based on the rate of the cell's DNA synthesis. Upon PET imaging, cell proliferation in tumors can be assessed as tumor cells have a higher rate of DNA synthesis than normal, healthy cells. This agent is not catabolized and has a long half-life compared to the radioconjugate carbon C 11 thymidine.NCI
code
  • C103278
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