About: Tumor-Cells Apoptosis Factor Hormone-Peptide     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Tumor-Cells Apoptosis Factor Hormone-Peptide
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Tumor-Cells Apoptosis Factor Hormone-Peptide
UMLS_CUI
  • C2974969
PDQ_Open_Trial_Search_ID
  • 740779
PDQ_Closed_Trial_Search_ID
  • 740779
FULL_SYN
  • Tumor-Cells Apoptosis Factor Hormone-PeptidePTNCI
  • NerofeFBNCI
DEFINITION
  • A synthetic 14-amino acid peptide derived from a novel human peptide hormone, Tumor-Cells Apoptosis Factor (TCApF), with potential antineoplastic activity. Upon intravenous administration, tumor-cells apoptosis factor hormone-peptide binds to the T1/ST2 receptor (IL1RL1) and activates both caspase 8 and Bcl-2 mediated apoptosis, in addition to the activation of p38 MAPK and JNK signaling cascades in tumor cells. Furthermore, this agent inhibits angiogenesis by suppressing the expressions of vascular endothelial growth factor A (VEGFA) and fms-related tyrosine kinase 1 (VEGFR1). Tumor-cells apoptosis factor hormone-peptide also modulates immune system responses via increasing the expressions of interleukin-10 and anti-angiogenic interleukin. T1/ST2 receptor, a member of the toll/interleukin-1 receptor superfamily, is overexpressed in certain cancer cells.NCI
code
  • C103193
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