About: Modified Citrus Pectin Supplement     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Modified Citrus Pectin Supplement
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Modified Citrus Pectin Supplement
NCI_META_CUI
  • CL437425
PDQ_Open_Trial_Search_ID
  • 740207
PDQ_Closed_Trial_Search_ID
  • 740207
FULL_SYN
  • Modified Citrus Pectin SupplementPTNCI
  • PectaSol-CBRNCI
DEFINITION
  • A dietary supplement containing the modified citrus pectin (MCP) derived from the soluble fiber of citrus fruit peels and a galectin-3 inhibitor with potential antioxidant, hypocholesterolemic, immunostimulatory, metal chelating, and anti-metastatic activities. MCP is a low molecular weight version of pectin composed of short, slightly-branched carbohydrate chains and is modified for enhanced absorbability. The bioactive fragments, most likely the galactan-containing portion, of pectin binds to galectin-3, a carbohydrate-binding protein involved in imflammation, heart disease and is upregulated on the surface of certain types of tumor cells. Binding of MCP may result in the suppression of cancer cell aggregation, adhesion, proliferation and metastasis. In addition, MCP decreases prostate specific antigen (PSA) levels and may remove heavy metals. Also, unsaturated oligogalacturonic acids in MCP may stimulate the immune system through the activation of natural killer cells, cytotoxic T-cells, and B-cells.NCI
code
  • C103178
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