About: S-Adenosylhomocysteine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • S-Adenosylhomocysteine
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
Preferred_Name
  • S-Adenosylhomocysteine
UMLS_CUI
  • C0036001
FULL_SYN
  • S-AdenosylhomocysteinePTNCI
  • S-Adenosyl-L-homocysteineSYNCI
  • SAHABNCI
  • AdoHCySYNCI
  • (S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosineSNNCI
DEFINITION
  • An amino acid derivative and an intermediate in the synthesis of cysteine and adenosine. S-adenosylhomocysteine (SAH) is formed upon S-adenosylmethionine (SAM)-dependent methylation (homocysteine methionine cycle) of biological molecules, such as DNA, RNA, and proteins. It is then hydrolyzed by S-adenosylhomocysteine hydrolase to form adenosine and homocysteine. As SAH modulates methylation dependent reactions, SAH levels and the ratio of SAH:SAM may be used to assess methylation status of macrocolecules.NCI
code
  • C103149
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