About: PBN Derivative OKN-007     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • PBN Derivative OKN-007
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • PBN Derivative OKN-007
UMLS_CUI
  • C2974636
CAS_Registry
  • 168021-79-2
PDQ_Open_Trial_Search_ID
  • 739669
PDQ_Closed_Trial_Search_ID
  • 739669
FULL_SYN
  • NXY-059CNNCI
  • 2,4-Disulfophenyl-tert-butylnitroneSNNCI
  • OKN007CNNCI
  • 2,4-Disulfonyl PBNSYNCI
  • OKN-007CNNCI
  • PBN Derivative OKN-007PTNCI
DEFINITION
  • A disulfonyl derivative of phenyl-tert-butyl nitrone (PBN), with potential anti-glioma activity. Although the exact mechanism(s) of action of OKN007 are still largely unknown, this agent appears to inhibit cancer cell proliferation and migration. This agent appears to inhibit the activity of sulfatase 2 (SULF2), a highly specific endoglucosamine-6-sulfatase that is overexpressed in the extracellular matrix of cancer cells and catalyzes the removal of sulfate from the 6-O-sulfate esters of heparin. In addition, OKN007 may induce changes in tumor metabolism and scavenge free radicals.NCI
code
  • C102983
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 48 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software