About: Threonine Aspartase 1     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Threonine Aspartase 1
rdfs:subClassOf
OMIM_Number
  • 608270
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Enzyme
Preferred_Name
  • Threonine Aspartase 1
NCI_META_CUI
  • CL437189
FULL_SYN
  • Taspase 1SYNCI
  • Taspase-1SYNCI
  • Threonine Aspartase 1PTNCI
  • EC 3.4.25.-SYNCI
Swiss_Prot
  • Q9H6P5
DEFINITION
  • Threonine aspartase 1 (420 aa, ~44 kDa) is encoded by the human TASP1 gene. This protein plays a role in the proteolysis of histone-lysine N-methyltransferase MLL protein.NCI
DesignNote
  • Threonine aspartase 1 undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble non-covalently into the active alpha2-beta2 heterotetramer. (EntrezGene and UniProt)
  • Threonine aspartase 1 cleaves histone-lysine N-methyltransferase MLL which both increases the stability and enhances the nuclear localization for the MLL protein. (OMIM)
code
  • C102896
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