About: Thioureidobutyronitrile     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Thioureidobutyronitrile
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Thioureidobutyronitrile
NCI_META_CUI
  • CL437184
PDQ_Open_Trial_Search_ID
  • 739050
PDQ_Closed_Trial_Search_ID
  • 739050
FULL_SYN
  • ThioureidobutyronitrilePTNCI
  • KevetrinBRNCI
DEFINITION
  • A water-soluble, small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. Upon intravenous administration, thioureidobutyronitrile activates p53 which in turn induces the expressions of p21 and PUMA (p53 up-regulated modulator of apoptosis), thereby inhibiting cancer cell growth and causing tumor cell apoptosis. Thioureidobutyronitrile may be effective in drug-resistant cancers with mutated p53. p53 tumor suppressor, a transcription factor regulating the expression of many stress response genes and mediating various anti-proliferative processes, is often mutated in cancer cells.NCI
code
  • C102881
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