About: Diammonium Glycyrrhizinate     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Diammonium Glycyrrhizinate
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Diammonium Glycyrrhizinate
UMLS_CUI
  • C1956193
CAS_Registry
  • 79165-06-3
PDQ_Open_Trial_Search_ID
  • 737610
PDQ_Closed_Trial_Search_ID
  • 737610
Chemical_Formula
  • C42H62O16.2H3N
FULL_SYN
  • alpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-Glucopyranuronosyl-, Diammonium Salt (9CI)SNNCI
  • Diammonium GlycyrrhizinatePTNCI
  • 18beta-Glycyrrhizic Acid DiammoniumsaltSYNCI
DEFINITION
  • The diammonium salt of glycyrrhizin and the active constituent in the traditional Chinese medicinal herb Glycyrrhiza uralensis (Chinese liquorice or Gan-Cao) with anti-inflammatory, antioxidant and hepatoprotective properties. Diammonium glycyrrhizinate (DG) is slowly metabolized within the cells into glycyrrhetic acid, which inhibits enzymes that control cortisol metabolism and contributes to this agent's anti-inflammatory effect. Although the exact mechanism of action remains to be fully elucidated, DG may prevent or reduce hepatotoxicity via the scavenging of free radicals. This agent also upregulates the expression of transcription coactivator PGC-1alpha and modulates hepatic enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), superoxide dismutase and glutathion peroxidase.NCI
code
  • C102865
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