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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Ulinastatin
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Ulinastatin
UMLS_CUI
  • C0077906
CAS_Registry
  • 80449-32-7
PDQ_Open_Trial_Search_ID
  • 737612
PDQ_Closed_Trial_Search_ID
  • 737612
FULL_SYN
  • UlinastatinPTNCI
  • Urinary Trypsin InhibitorSYNCI
  • UTIABNCI
DEFINITION
  • A multivalent Kunitz-type serine protease inhibitor derived from human urine, with potential protective, anti-fibrinolytic and anticoagulant activities. Upon administration, ulinastatin (or urinary trypsinogen inhibitor) inhibits the activities of a variety of enzymes, including trypsin, chymotrypsin, thrombin, kallikrein, plasmin, elastase, cathepsin, lipase, hyaluronidase, factors IXa, Xa, XIa, and XlIa, and polymorphonuclear leukocyte elastase. In addition, ulinastatin inhibits the excessive release of proinflammatory mediators, such as tumor necrosis factor-alpha, interleukin-6 and -8, and chemokines. Altogether, this agent may improve the microcirculation, perfusion and function of tissues and may protect organ injury.NCI
code
  • C102851
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