About: CK2-targeting Synthetic Peptide CIGB-300     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • CK2-targeting Synthetic Peptide CIGB-300
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • CK2-targeting Synthetic Peptide CIGB-300
UMLS_CUI
  • C2605865
PDQ_Open_Trial_Search_ID
  • 737263
PDQ_Closed_Trial_Search_ID
  • 737263
FULL_SYN
  • P15-tatCNNCI
  • CK2-targeting Synthetic Peptide CIGB-300PTNCI
  • CIGB-300CNNCI
DEFINITION
  • A synthetic peptide targeting the substrates of casein kinase 2 (CK2), with potential antineoplastic activity. Upon administration and nucleolar localization, CK2-targeting synthetic peptide CIGB-300 binds to phosphoacceptor sites on the CK2 substrates, in particular the oncoprotein nucleophosmin (B23 or NPM1). This blocks the activation of B23 and induces apoptosis, thereby inhibiting tumor cell growth in susceptible tumor cells. CK2, a protein kinase often overexpressed in a variety of cancer cell types, appears to be correlated with malignant transformation, tumor growth and survival. Overexpression of B23 has been correlated with increased cellular growth and proliferation as well as inhibition of differentiation and apoptosis.NCI
code
  • C102849
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