About: Inducible CD4+CD25+ Regulatory T Cells     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Inducible CD4+CD25+ Regulatory T Cells
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Inducible CD4+CD25+ Regulatory T Cells
NCI_META_CUI
  • CL437026
PDQ_Open_Trial_Search_ID
  • 737145
PDQ_Closed_Trial_Search_ID
  • 737145
FULL_SYN
  • Inducible CD4+CD25+ Regulatory T CellsPTNCI
  • iTregsSYNCI
DEFINITION
  • Inducible regulatory T-lymphocytes that express CD4, CD25 (the alpha chain of the interleukin 2 receptor) and forkhead box P3 (FOXP3), with potential immunomodulating activity. Inducible CD4+CD25+ T regulatory cells (iTregs) are a subset of CD4+ T lymphocytes that are induced from CD25- precursors in peripheral lymphoid organs with interleukin-2 and transforming growth factor-beta. These regulatory T cells are essential in maintaining immunologic homeostasis. They may also prevent autoimmunity by suppressing self-reactive T cells, and may induce tolerance to allogeneic organ transplants such as in hematopoietic stem cell transplants.NCI
code
  • C102789
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