About: Bryostatin 1

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Attributes	Values
rdf:type	Class
rdfs:label	Bryostatin 1
equivalentClass	nodeID://b630495
Has_Target	Protein Kinase C
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Bryostatin 1
NSC_Code	339555
UMLS_CUI	C0054173
CAS_Registry	83314-01-6
In_Clinical_Trial_For	Acute myeloid leukemia; Chronic lymphocytic leukemia; Leukemia; Lymphoma; Non-Hodgkins lymphoma; Refractory myeloid cancer; Small intestine cancer; Solid tumor, adult
FDA_UNII_Code	37O2X55Y9E
Contributing_Source	FDA
ALT_DEFINITION	A substance being studied in the treatment of cancer and certain brain conditions such as Alzheimer disease and stroke. It binds to an enzyme involved in cell growth and it may help anticancer drugs work better. Bryostatin 1 comes from a marine organism. It is a type of protein kinase C modulator.NCI-GLOSS
PDQ_Open_Trial_Search_ID	41959
PDQ_Closed_Trial_Search_ID	41959
Chemical_Formula	C47H68O17
Legacy_Concept_Name	Bryostatin-1
FULL_SYN	Bryostatin 1SYDTPNSC0339555 Bryostatin 1PTNCI bryostatin 1PTNCI-GLOSSCDR0000045630 Bryostatin IPTDCP01979 B705008K112SYDTPNSC0339555 B705008K112CNNCI BRYOSTATIN 1PTFDA37O2X55Y9E
DEFINITION	A macrocyclic lactone isolated from the bryozoan Bugula neritina with antineoplastic activity. Bryostatin 1 binds to and inhibits the cell-signaling enzyme protein kinase C, resulting in the inhibition of tumor cell proliferation, the promotion of tumor cell differentiation, and the induction of tumor cell apoptosis. This agent may act synergistically with other chemotherapeutic agents. (NCI04)NCI
code	C1026
is someValuesFrom of	nodeID://b651791 nodeID://b651792 nodeID://b651794 nodeID://b651797 nodeID://b651799 nodeID://b651800 nodeID://b651802 nodeID://b651806 nodeID://b651808 nodeID://b651810 nodeID://b651812

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