About: Recombinant EphB4-HSA Fusion Protein     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Recombinant EphB4-HSA Fusion Protein
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Recombinant EphB4-HSA Fusion Protein
NCI_META_CUI
  • CL436876
PDQ_Open_Trial_Search_ID
  • 735271
PDQ_Closed_Trial_Search_ID
  • 735271
FULL_SYN
  • Recombinant EphB4-HSA Fusion ProteinPTNCI
  • sEphB4-HSAABNCI
DEFINITION
  • A recombinant fusion protein composed of the full-length extracellular domain (soluble) of human receptor tyrosine kinase ephrin type-B receptor 4 (sEphB4) and fused, at its C-terminus, to full-length human serum albumin (HSA), with potential antineoplastic and anti-angiogenic activities. sEphB4-HSA functions as a decoy receptor for the membrane-bound ligand Ephrin-B2 (Efnb2) and interferes with the binding of Efnb2 to its native receptors, including EphB4 and EphA3. This may result in a reduction of angiogenesis and a reduction in cell growth of Efnb2 and/or EphB4 over-expressing tumor cells. In addition, this agent also prevents the angiogenic effects of numerous growth factors due to interactions between Efnb2 and EphB4. Efnb2 and EphB4 are overexpressed in a variety of tumor cell types; the bi-directional signaling of Efnb2-EphB4 plays an important role in angiogenesis and tumor cell migration, invasion, and proliferation. Albumin reduces this agent's degradation, improves circulation time and may thus improve efficacy.NCI
code
  • C102569
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