About: Docetaxel Lipid Microspheres     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Docetaxel Lipid Microspheres
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Docetaxel Lipid Microspheres
NCI_META_CUI
  • CL436875
PDQ_Open_Trial_Search_ID
  • 735255
PDQ_Closed_Trial_Search_ID
  • 735255
FULL_SYN
  • Docetaxel Lipid EmulsionSYNCI
  • DLEABNCI
  • DT-LMABNCI
  • Docetaxel Lipid MicrospheresPTNCI
DEFINITION
  • A lipid microsphere (LM)-based formulation containing the poorly water soluble taxane docetaxel, a semi-synthetic analogue of paclitaxel, with antineoplastic activity. Docetaxel binds specifically to the beta-tubulin subunit of the microtubule, stabilizing tubulin and inhibiting microtubule disassembly, which causes cell cycle arrest at the G2/M phase and leads to cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and induces various mediators of the inflammatory response. Compared to docetaxel alone, the LM formulation may enhance stability, improve efficacy and may reduce toxicity; this formulation does not contain toxic detergents needed to solubilize docetaxel which further improves its side effect profile.NCI
code
  • C102568
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