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AttributesValues
rdf:type
rdfs:label
  • Emitefur
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Emitefur
UMLS_CUI
  • C0053902
CAS_Registry
  • 110690-43-2
FDA_UNII_Code
  • 9I50NF4AQ2
Contributing_Source
  • FDA
ALT_DEFINITION
  • An anticancer drug that belongs to the family of drugs called antimetabolites.NCI-GLOSS
Chemical_Formula
  • C28H19FN4O8
Legacy_Concept_Name
  • Emitefur
FULL_SYN
  • (2) m-[[3-(Ethoxymethyl)-5-fluoro-3,6-dihydro-2,6-dioxo-1(2H)-pyrimidinyl]carbonyl]benzoic Acid, 2-Ester with 2,6-Dihydroxynicotinonitrile Benzoate (Ester)SNNCI
  • 3-[[3-(Ethoxymethyl)-5-fluoro-3.6-dihydro-2,6-dioxo-1(2H0-pyrimidinyl]carbonyl]benzoic Acid 6-(Benzoyloxy)-3-cyano-2-pyridinyl EsterSNNCI
  • 3-[3-(6-Benzoyloxy-3-cyrano-2-pyridyloxycarbonyl)benzoyl]-1-(ethoxymethyl)-5-fluorouracilSNNCI
  • Ethoxymethyl-5-fluoro-3,6-dihydro-2,6-dioxo-1(2H)-pyrimidinyl]carbonyl]benzoic Acid, 6-(Benzoyloxy)-3-cyano-2-pyridinyl EsterSNNCI
  • EMITEFURPTFDA9I50NF4AQ2
  • BOF-A2CNNCI
  • Last-FFBNCI
  • emitefurPTNCI-GLOSSCDR0000045578
  • EmitefurPTNCI
DEFINITION
  • An orally available antimetabolite composed of the 1-ethoxymethyl derivative of 5-fluorouracil (5-FU) and the dihydropyrimidine dehydrogenase (DPYD) inhibitor 3-cyano-2,6-dihydroxypyridine (CNDP) in a 1:1 molar ratio, with antineoplastic activity. Upon administration, the prodrug emitefur is converted into 5-FU, while CNDP prevents the degradation of 5-FU by inhibiting DPYD and thereby prolonging the half-life of 5-FU. This increases 5-FU's concentration and thus its antitumor activity through inhibition of DNA and RNA synthesis, as well as inhibition of thymidylate synthase activity. In addition, by inhibiting the formation of 5-FU metabolites, some toxic effects associated with these metabolites may be reduced. DPYD is the rate-limiting enzyme in the catabolism of 5-FU.NCI
code
  • C1022
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