About: Mesothelin-specific Chimeric Antigen Receptor-engineered Peripheral Blood Lymphocytes     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Mesothelin-specific Chimeric Antigen Receptor-engineered Peripheral Blood Lymphocytes
rdfs:subClassOf
Semantic_Type
  • Cell
  • Pharmacologic Substance
Preferred_Name
  • Mesothelin-specific Chimeric Antigen Receptor-engineered Peripheral Blood Lymphocytes
NCI_META_CUI
  • CL435898
PDQ_Open_Trial_Search_ID
  • 732671
PDQ_Closed_Trial_Search_ID
  • 732671
FULL_SYN
  • Mesothelin-specific Chimeric Antigen Receptor-engineered Peripheral Blood LymphocytesPTNCI
  • Anti-mesothelin CAR PBLSYNCI
DEFINITION
  • A preparation of peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding a T cell chimeric antigen receptor (CAR) specific for mesothelin with potential immunostimulatory and antineoplastic activities. After transduction, expansion in culture, and reintroduction into the patient, the mesothelin-specific chimeric antigen receptor-engineered PBLs bind to tumor cells expressing mesothelin. This may stimulate the secretion of cytokines and result in cell lysis of mesothelin-expressing cancer cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in many epithelial-derived cancers.NCI
code
  • C101773
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