About: Anti-GCC Antibody-Drug Conjugate MLN0264     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Anti-GCC Antibody-Drug Conjugate MLN0264
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Anti-GCC Antibody-Drug Conjugate MLN0264
NCI_META_CUI
  • CL435781
PDQ_Open_Trial_Search_ID
  • 732254
PDQ_Closed_Trial_Search_ID
  • 732254
FULL_SYN
  • MLN0264CNNCI
  • Anti-GCC Antibody-Drug Conjugate MLN0264PTNCI
DEFINITION
  • An antibody-drug conjugate (ADC) containing a monoclonal antibody directed against guanylyl cyclase C (GCC or GUCY2C) conjugated to monomethylauristatin E (MMAE), an auristatin derivative and a potent microtubule inhibitor, with potential antineoplastic activity. The monoclonal antibody moiety of MLN0264 selectively binds to GCC, a transmembrane receptor normally found on intestinal cells and dopamine neurons in the brain, but is also overexpressed on the surface of gastrointestinal cancers. Upon internalization and proteolytic cleavage, MMAE binds to tubulin and inhibits its polymerization, resulting in G2/M phase arrest and tumor cell apoptosis in GCC-expressing tumor cells.NCI
code
  • C101524
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