About: FMS Inhibitor JNJ-40346527     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • FMS Inhibitor JNJ-40346527
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • FMS Inhibitor JNJ-40346527
NCI_META_CUI
  • CL435776
PDQ_Open_Trial_Search_ID
  • 730665
PDQ_Closed_Trial_Search_ID
  • 730665
FULL_SYN
  • JNJ-40346527CNNCI
  • FMS Inhibitor JNJ-40346527PTNCI
DEFINITION
  • A small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; FMS) with potential antineoplastic activity. FMS tyrosine kinase inhibitor JNJ-40346527 blocks the receptor-ligand interaction between FMS and its ligand CSF1, thereby preventing autophosphorylation of FMS. As a result, unphosphorylated FMS can not activate FMS-mediated signaling pathways, thus potentially inhibiting cell proliferation in FMS-overexpressed tumor cells. FMS, a tyrosine kinase receptor, is overexpressed in certain tumor cell types and plays an essential role in macrophage differentiation, recruitment, and activation as well as the regulation of cell proliferation.NCI
code
  • C101519
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