About: CD-expressing Bifidobacterium APS001F     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • CD-expressing Bifidobacterium APS001F
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • CD-expressing Bifidobacterium APS001F
NCI_META_CUI
  • CL435547
PDQ_Open_Trial_Search_ID
  • 729923
PDQ_Closed_Trial_Search_ID
  • 729923
FULL_SYN
  • CD-expressing Bifidobacterium APS001FPTNCI
  • APS001FCNNCI
DEFINITION
  • A recombinant anaerobic bacterium, Bifidobacterium longum, encoding the cytosine deaminase (CD) gene with potential antineoplastic adjuvant activity. Upon injection, the CD-expressing bifidobacterium preferentially localizes and grows in the hypoxic environment of the tumor and expresses CD, an enzyme that catalyzes the intracellular conversion of the prodrug flucytosine (5-FC) into the antineoplastic agent 5-fluorouracil (5-FU). Upon administration of 5-FC, and subsequent localized conversion into 5-FU and its cytotoxic active metabolites, the tumor is specifically exposed to cytotoxic agents while the exposure to normal tissues is minimal.NCI
code
  • C101367
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