About: Multifunctional/Multitargeted Anticancer Agent OMN54     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Multifunctional/Multitargeted Anticancer Agent OMN54
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Multifunctional/Multitargeted Anticancer Agent OMN54
NCI_META_CUI
  • CL435508
PDQ_Open_Trial_Search_ID
  • 729454
PDQ_Closed_Trial_Search_ID
  • 729454
FULL_SYN
  • Multifunctional/Multitargeted Anticancer Agent OMN54PTNCI
  • OMN54CNNCI
  • AneustatBRNCI
  • MFMT OMN54SYNCI
DEFINITION
  • An orally available, multivalent herbal formulation containing a novel mixture of whole extracts from three commonly used Chinese medicinal herbs Ganoderma lucidum (lingzhi mushroom), Salvia miltiorrhiza (Chinese sage, or danshen) and Scutellaria barbata (ban zhi lian), with potential immunomodulating, antiangiogenic, anti-inflammatory, antiproliferative and antiviral activities. Although the exact mechanism of action remains to be fully elucidated due to the complexity of the multiple phytochemicals, multifunctional/multitargeted anticancer agent OMN54 appears to work in an additive and synergistic manner by acting on a variety of signaling pathways and on multiple targets, such as vascular endothelial growth factor, nuclear factor kappa B, interleukin-1beta, fibroblast growth factor, and epidermal growth factor.NCI
code
  • C101260
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