About: Pegylated Recombinant L-asparaginase Erwinia chrysanthemi

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About: Pegylated Recombinant L-asparaginase Erwinia chrysanthemi Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	Class
rdfs:label	Pegylated Recombinant L-asparaginase Erwinia chrysanthemi
rdfs:subClassOf	ANTINEOPLASTICS
Semantic_Type	Enzyme Pharmacologic Substance
Preferred_Name	Pegylated Recombinant L-asparaginase Erwinia chrysanthemi
NCI_META_CUI	CL435507
PDQ_Open_Trial_Search_ID	729150
PDQ_Closed_Trial_Search_ID	729150
FULL_SYN	Pegylated Recombinant L-asparaginase Erwinia chrysanthemiPTNCI AsparecFBNCI mPEG-R-crisantaspaseSYNCI
DEFINITION	A pegylated, recombinant form of L-asparaginase derived from the bacterium Erwinia chrysanthemi (mPEG-R-Crisantaspase), with potential antineoplastic activity. Upon intravenous administration of pegylated recombinant L-asparaginase Erwinia chrysanthemi, asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia, thereby depleting cancer cells of asparagine thus blocking protein synthesis and tumor cell proliferation. Asparagine is critical to protein synthesis in cancer cells, which cannot synthesize this amino acid due to the absence of the enzyme asparagine synthase. Compared to other available Erwinia chrysanthemi derived L-asparaginase agents, the pegylated form is longer acting and less immunogenic.NCI
code	C101259

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