About: IGF-1R Antisense Oligodeoxynucleotide-treated Autologous Glioma Cells     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • IGF-1R Antisense Oligodeoxynucleotide-treated Autologous Glioma Cells
rdfs:subClassOf
Semantic_Type
  • Cell
  • Pharmacologic Substance
Preferred_Name
  • IGF-1R Antisense Oligodeoxynucleotide-treated Autologous Glioma Cells
NCI_META_CUI
  • CL435505
PDQ_Open_Trial_Search_ID
  • 729046
PDQ_Closed_Trial_Search_ID
  • 729046
FULL_SYN
  • IGF-1R/AS ODN-treated Autologous Glioma CellsSYNCI
  • IGF-1R Antisense Oligodeoxynucleotide-treated Autologous Glioma CellsPTNCI
DEFINITION
  • Autologous glioma cells treated ex vivo with an 18-mer antisense oligodeoxynucleotide of insulin-like growth factor receptor 1 (IGF-1R/AS ODN), with potential antineoplastic activity. IGF-1R/AS ODN pre-treated glioma cells encapsulated in small Lucite diffusion chambers are implanted into a subcutaneous pocket in the patient's abdominal rectus sheath. Within the diffusion chambers, IGF-1R/AS ODN binds to IGF-1R mRNA, and shuts down the translation of IGF-1R in the glioma cells. Downregulation of IGF-1R induces apoptosis and causes the release of exosomes, which contain tumor-associated antigens (TAAs). The diffusion of exosomes and IGF-1R/AS ODN from the Lucite chambers may active the patient's immune system and mount a cytotoxic T-lymphocyte (CTL) response against cells expressing these TAAs. IGF-1R, a receptor tyrosine kinase, is overexpressed in a variety of tumor cell types and is essential for tumor cell growth, transformation and survival.NCI
code
  • C101257
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