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AttributesValues
rdf:type
rdfs:label
  • Aldosterone Receptor Antagonist
rdfs:subClassOf
Semantic_Type
  • Chemical Viewed Functionally
Preferred_Name
  • Aldosterone Receptor Antagonist
UMLS_CUI
  • C1579268
FULL_SYN
  • Aldosterone Receptor AntagonistPTNCI
DEFINITION
  • A class of agents that act by selectively inhibiting aldosterone receptor activation with diuretic activity. Aldosterone receptor antagonists bind to and block the activation of aldosterone (mineralocorticoid) receptors on the epithelial cells in the late distal tubule and collecting duct of the kidney, thus preventing the synthesis of aldosterone-induced proteins which enhance Na+ retention and K+ and H+ secretion. The enhanced excretion of Na+ produces diuresis ultimately resulting in a reduction in blood pressure without the loss of K+.NCI
code
  • C101255
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