About: Erythrocyte-encapsulated L-asparaginase Suspension     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Erythrocyte-encapsulated L-asparaginase Suspension
rdfs:subClassOf
Semantic_Type
  • Enzyme
  • Pharmacologic Substance
Preferred_Name
  • Erythrocyte-encapsulated L-asparaginase Suspension
NCI_META_CUI
  • CL433492
PDQ_Open_Trial_Search_ID
  • 724517
PDQ_Closed_Trial_Search_ID
  • 724517
FULL_SYN
  • GRASPASYNCI
  • Erythrocyte-encapsulated L-asparaginase SuspensionPTNCI
DEFINITION
  • A suspension of erythrocytes encapsulating L-asparaginase with potential antineoplastic activity. Upon administration of erythrocyte-encapsulated L-asparaginase suspension, L-asparagine is hydrolyzed to L-aspartic acid and ammonia in plasma, thereby depleting tumor cells of asparagine. Due to low asparagine synthetase activity in tumor cells, de novo synthesis of asparagine is suppressed within tumor cells. Shortage of asparagine prevents synthesis of important proteins necessary for tumor cell growth. Encapsulation of asparaginase in erythrocytes decreases the immunogenicity of exogenous protein, enhances its circulation time and may limit toxicity.NCI
code
  • C99767
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