About: Cevipabulin Succinate     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Cevipabulin Succinate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Cevipabulin Succinate
NCI_META_CUI
  • CL429369
CAS_Registry
  • 852954-81-5
FDA_UNII_Code
  • 8XI0CX98LY
Contributing_Source
  • FDA
Chemical_Formula
  • C18H18ClF5N6O.C4H6O4.2H2O
FULL_SYN
  • 5-chloro-6-(2,6-difluoro-4-(3-(methylamino)propoxy)phenyl)-N-((1S)-2,2,2-trifluoro-1-methylethyl)(1,2,4)triazolo(1,5-a)pyrimidin-7-amine succinate dihydrateSNNCI
  • CEVIPABULIN SUCCINATEPTFDA8XI0CX98LY
  • TTI-237 Succinate DihydrateCNNCI
  • Cevipabulin SuccinatePTNCI
DEFINITION
  • The succinate salt form of cevipabulin, a synthetic, water soluble tubulin-binding agent with potential antineoplastic activity. Cevipabulin binds at the vinca-binding site on tubulin, but seems to act more similar to taxane-site binding agents in that it enhances tubulin polymerization and does not induce tubulin depolymerization. This stabilizes tubulin and prevents microtubule disassembly. The disruption in microtubule dynamics may eventually inhibit cell division and reduce cellular growth.NCI
code
  • C96746
is Has_Salt_Form of
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