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AttributesValues
rdf:type
rdfs:label
  • Peretinoin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Peretinoin
UMLS_CUI
  • C2828216
CAS_Registry
  • 81485-25-8
FDA_UNII_Code
  • 11ALM7A4RV
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 737371
PDQ_Closed_Trial_Search_ID
  • 737371
Chemical_Formula
  • C20H30O2
FULL_SYN
  • NIK-333CNNCI
  • PERETINOINPTFDA11ALM7A4RV
  • (2E,4E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,4,6,10,14-Pentaenoic AcidSNNCI
  • PeretinoinPTNCI
DEFINITION
  • An orally available, acyclic retinoid with potential antineoplastic and chemopreventive activities. Peretinoin binds to and activates nuclear retinoic acid receptors (RAR), which in turn recruit coactivator proteins and promote, with other transcriptional complexes, the transcription of target genes. As a result, this agent may modulate the expression of genes involved in the regulation of cell proliferation, cell differentiation, and apoptosis of both normal and tumor cells.NCI
code
  • C87202
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