About: Camptothecin Analogue TLC388     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Camptothecin Analogue TLC388
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Camptothecin Analogue TLC388
UMLS_CUI
  • C2703206
PDQ_Open_Trial_Search_ID
  • 615096
PDQ_Closed_Trial_Search_ID
  • 615096
Legacy_Concept_Name
  • Camptothecin_Analogue_TLC388
FULL_SYN
  • Camptothecin Analogue TLC388PTNCI
  • TLC388CNNCI
  • LipotecanBRNCI
DEFINITION
  • A synthetic analogue of camptothecin with potential antineoplastic and radio-sensitizing activities. Camptothecin analogue TLC388 selectively stabilizes topoisomerase I-DNA covalent complexes during S-phase, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. Topoisomerase I relaxes negative super-coiled DNA during replication and transcription. This agent has been chemically modified to enhance the potency and stability of camptothecin.NCI
code
  • C80047
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