About: Integrin Alpha-IIb/Beta-3     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Integrin Alpha-IIb/Beta-3
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • Integrin Alpha-IIb/Beta-3
UMLS_CUI
  • C0016011
Legacy_Concept_Name
  • Integrin_Alpha-IIb_Beta-3
FULL_SYN
  • Integrin Alpha-2b/Beta-3SYNCI
  • Alpha2b/Beta3SYNCI
  • Integrin Alpha-IIb/Beta-3PTNCI
  • Alpha 2b/Beta 3SYNCI
  • Alpha-IIb/Beta-3SYNCI
  • Glycoprotein IIb/IIIaSYNCI
  • gpIIb/IIIaSYNCI
DEFINITION
  • Integrin alpha-IIb/beta3 is a protein complex comprised of a heterodimer of integrin alpha 2b and integrin beta 3. This complex is involved in cell adhesion and blood clot formation.NCI
DesignNote
  • Integrin Alpha-IIb/Beta3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the amino acid sequence R-G-D in a wide array of ligands and H-H-L-G-G-G-A-K-Q-A-G-D-V in the fibrinogen gamma chain. Following activation, integrin alpha-IIb/beta-3 binds to soluble fibrinogen and catalyzes rapid platelet aggregation. (UniProt)
code
  • C77161
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