About: CDK Inhibitor P276-00     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • CDK Inhibitor P276-00
rdfs:subClassOf
Has_Target
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • CDK Inhibitor P276-00
UMLS_CUI
  • C1832023
PDQ_Open_Trial_Search_ID
  • 529362
PDQ_Closed_Trial_Search_ID
  • 529362
Legacy_Concept_Name
  • P276
FULL_SYN
  • P276CNNCI
  • Cyclin Dependent Kinase Inhibitor P276SYNCI
  • P276-00CNNCI
  • CDK Inhibitor P276-00PTNCI
DEFINITION
  • A flavone and cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity. P276-00 selectively binds to and inhibits Cdk4/cyclin D1, Cdk1/cyclin B and Cdk9/cyclin T1, serine/threonine kinases that play key roles in the regulation of the cell cycle and cellular proliferation. Inhibition of these kinases leads to cell cycle arrest during the G1/S transition, thereby leading to an induction of apoptosis, and inhibition of tumor cell proliferation.NCI
code
  • C64762
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 83 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software