About: IL22 Signaling Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	IL22 Signaling Pathway
rdfs:subClassOf	Signaling Pathway
Semantic_Type	Functional Concept
Preferred_Name	IL22 Signaling Pathway
UMLS_CUI	C1512592
BioCarta_ID	h_il22bppathway
ALT_DEFINITION	IL-22 is an inflammatory cytokine related to IL-10 that is produced by T cells and that induces a response in cells through a heterodimeric cell surface receptor composed of IL-22R1 and IL-10R2C. One of the actions of IL-22 appears to be the induction of acute phase inflammatory response in hepatocytes, acting through activation of STATs and transcriptional regulation. A gene with homology to the extracellular domain of the cell surface IL-22R1 receptor component was identified that lacked transmembrane and cytoplasmic domains. The protein derived from this gene was found to bind IL-22 and block its interaction with the cell surface receptor. The IL-22 soluble receptor (IL-22BP, IL-22 binding protein) also blocks some of the downstream effects of IL-22 such as STAT activation and the transcriptional induction of genes involved in the immune and inflammatory responses. The IL-22 soluble receptor may act as an anti-inflammatory agent.BIOCARTA
Legacy_Concept_Name	IL22_Signaling_Pathway
FULL_SYN	IL22 Signaling PathwayPTNCI IL22 Soluble Receptor Signaling PathwayPTBIOCARTA
code	C39121
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